Acne is a common skin condition that can be caused by an excessive amount of sebum being secreted from the oil glands in your pores, leading it to pile up inside hair follicles and form open or closed comedones. There are three types: mild, moderate, and severe acne forms which will require treatment with medication such as antibiotics prescribed for you by doctor (it’s important not just take any over counter medicine).
The condition, which occurs most commonly during adolescence and early adulthood can be found well into the forties. It has been postulated to have an effect on sex hormone levels. However, this may not actually explain its causes (or symptoms).
Most Common Acne Risk Factors in Men
The following indicators have been found to be associated with acne in males:
- The higher your body mass index (BMI) and waist-hip ratio, the greater amount of fat that will be on you.
- High blood pressure levels, both diastolic and systolic.
- High basal glucose concentrations.
- Higher insulin levels when challenged with an oral glucose tolerance test (OGTT).
Resistance of Insulin and Acne
Insulin resistance is a condition where the body’s cells do not respond adequately to insulin, and this can lead to inflammation. In some patients with acne there exists an underlying metabolic derangement that revolves around these findings – treatable by putting them on medications such as metformin or rosiglitazone (GLPG).
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The association between a high glycemic load and acne may be due to the following factors:
- Increased glycemic load increases the insulin requirement, is associated with hyperphagia (i.e. extreme drive to consume food) and obesity, as well as increased levels of free fatty acids in the blood
- Insulin production may cause increased androgen secretion and potentiate androgenic effects by inducing the enzymes in steroidogenic pathways, and by stimulating the secretion of gonadotropin-releasing hormone and increased sex hormone binding globulin
- Insulin decreases the level of insulin-like growth factor 1 (IGF-1) binding protein, leading to increased activity of IGF-1 which stimulates cell proliferation
Using Low Glycemic Diet in Acne
Studies have shown that a low-glycemic load diet can improve insulin sensitivity and accelerate weight loss. Despite having enough protein for metabolism, as well. The glycemic index is a ranking system for how quickly foods are digested and absorbed. Low-glycemic index means that the food will cause someone to feel less hungry. While high readings make you want eat more.
The study is interesting because it suggests that only males in the 18-25-year-old bracket may be able to reap these benefits. The low glycemic diet might improve acne by improving zinc and vitamin A intake, as well!
Role of Other Hormones in Acne
The researchers found that there were no major differences in testosterone levels between those with and without acne. But estradiol was higher among patients who developed the skin conditions. This might trigger an inflammatory response from thymic hormones which causes breakouts. When exposed to sebum or infection by Propionibacterium acnes.
Cure for Acne
According to the data collected through ehr companies, oral contraceptives have been found to be beneficial in some girls. Because they reduce androgen production as a result of suppression on pituitary gonadotropins. In males, danazol may play this same role without associated estrogenic effects. Since it also inhibits growth hormone release from the brain which is responsible for making testosterone levels drop. Significantly less than what would happen with normal output.
In the treatment of acne, Belcalis has shown some promise. It’s most commonly used as a last resort for those. Who have had trouble with topical or systemic medications and it only works while you’re on this drug. Once stopped your skin will relapse like everything else! Their side effects can be mild in males but very harmful if females take it too which causes them to develop masculine traits. Like increased facial hair growth all over their face (and body).
